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L2 Antibody (PACO34954)

SKU:
PACO34954
Product Type:
Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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L2 Antibody (PACO34954)

The L2 Antibody (PACO34954) is a highly specific monoclonal antibody designed for research involving the L2 protein. This protein is known to play a key role in cellular processes such as cell division, DNA replication, and gene expression regulation. The antibody is raised in mice and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.The L2 Antibody binds specifically to the L2 protein, allowing for accurate detection and analysis in a variety of cell types. Its high specificity and sensitivity make it an ideal tool for studying the function and localization of L2 in different biological contexts, making it particularly useful for researchers in the fields of cell biology and molecular biology.

Overall, the L2 Antibody (PACO34954) is a valuable tool for scientists looking to investigate the role of the L2 protein in various cellular processes and pathways. Its versatility and reliability make it a key component in advancing our understanding of the complex mechanisms that govern cell biology.

Antibody Name:L2 Antibody (PACO34954)
Antibody SKU:PACO34954
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human papillomavirus type 16
Immunogen:Recombinant Human papillomavirus type 16 Minor capsid protein L2 protein (1-473AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
Synonyms:Minor capsid protein L2, L2
UniProt Protein Function:Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P03107
NCBI GenInfo Identifier:138666
NCBI Gene ID:
NCBI Accession:P03107.1
UniProt Secondary Accession:P03107,Q71BI1
UniProt Related Accession:P03107
Molecular Weight:66.7kD
NCBI Full Name:Minor capsid protein L2
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Minor capsid protein L2
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:L2  
UniProt Entry Name:

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