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L1 Antibody (PACO32588)

SKU:
PACO32588
Product Type:
Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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L1 Antibody (PACO32588)

The L1 antibody (PAC032588) offered by Assay Genie is a valuable tool for research involving the L1 cell adhesion molecule. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for Western blot applications. By binding to the L1 protein, this antibody enables detection and analysis in a variety of cell types, making it a versatile option for studies in the fields of neurobiology and cancer research.The L1 cell adhesion molecule is known for its role in promoting cell-cell adhesion and signaling in the nervous system, making it crucial for processes such as axon guidance and neuronal migration.

Dysregulation of L1 expression has been linked to neurological disorders such as autism and schizophrenia, as well as tumor progression in various types of cancer. Therefore, further exploration of the mechanisms involving L1 is essential for advancing our understanding of these conditions and developing potential therapeutic interventions.

Antibody Name:L1 Antibody (PACO32588)
Antibody SKU:PACO32588
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human papillomavirus type 16
Immunogen:Recombinant Human papillomavirus type 16 Major capsid protein L1 protein (6-471AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Synonyms:Major capsid protein L1, L1
UniProt Protein Function:Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P03101
NCBI GenInfo Identifier:978128213
NCBI Gene ID:
NCBI Accession:P03101.3
UniProt Secondary Accession:P03101,O00530
UniProt Related Accession:P03101
Molecular Weight:56,278 Da
NCBI Full Name:Major capsid protein L1
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Major capsid protein L1
UniProt Synonym Protein Names:
Protein Family:Packaging protein
UniProt Gene Name:L1  
UniProt Entry Name:

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