The L-Selectin Polyclonal Antibody (CAB1622) is a valuable tool for researchers studying L-Selectin, a cell adhesion molecule involved in immune cell trafficking and activation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for various experimental techniques, including Western blotting.L-Selectin, also known as CD62L, plays a critical role in mediating the binding of immune cells to endothelial cells, allowing for their migration into lymphoid tissues and sites of inflammation. Its expression and function have been implicated in various immune-mediated processes, such as leukocyte recruitment, homing, and activation.
By utilizing the L-Selectin Polyclonal Antibody, researchers can gain valuable insights into the expression levels and localization of L-Selectin in different cell types and tissues. This can provide important information for understanding the role of L-Selectin in immune responses, inflammation, and disease pathology, ultimately leading to potential therapeutic strategies targeting L-Selectin in conditions such as inflammatory disorders and cancer.
Product Name:
SELL Rabbit Polyclonal Antibody
SKU:
CAB1622
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD62L/L-Selectin (NP_000646.2).
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6402
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD62L/L-Selectin Rabbit pAb (CAB1622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
