The Kynureninase Polyclonal Antibody (CAB6643) is a valuable tool for researchers studying kynureninase, an enzyme involved in the metabolism of tryptophan along the kynurenine pathway. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in Western blot applications. By binding to the kynureninase protein, this antibody enables researchers to detect and analyze the enzyme in a variety of cell types, making it a valuable resource for studies in immunology, neuroscience, and metabolic disorders.Kynureninase plays a crucial role in the catabolism of tryptophan, a key amino acid involved in immune regulation and neurotransmitter synthesis. Dysregulation of the kynurenine pathway has been implicated in a variety of diseases, including autoimmune disorders, neurodegenerative diseases, and psychiatric disorders.
By understanding the activity of kynureninase, researchers can gain insight into the mechanisms underlying these conditions and develop targeted therapies to treat them.Overall, the Kynureninase Polyclonal Antibody (CAB6643) is a valuable tool for researchers investigating the role of kynureninase in health and disease. Its high specificity and sensitivity make it an ideal choice for studying the enzyme in a variety of experimental settings, paving the way for advancements in biomedical research and the development of novel therapeutic interventions.
Product Name:
KYNU Rabbit Polyclonal Antibody
SKU:
CAB6643
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human KYNU (NP_001028170.1).
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8942
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using KYNU Rabbit pAb (CAB6643) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): HAP1Exposure time: 45s.
