| Background: | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid, (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond By similarity. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). |
| Synonyms: | Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III), KYAT3, CCBL2 KAT3 |
| UniProt Protein Function: | CCBL2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Lyase; EC 2.6.1.63; EC 2.6.1.7; EC 4.4.1.13; TransferaseChromosomal Location of Human Ortholog: 1p22.2Cellular Component: mitochondrionMolecular Function: cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; protein homodimerization activity; pyridoxal phosphate bindingBiological Process: 2-oxoglutarate metabolic process; amino acid metabolic process; biosynthetic process; tryptophan catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q6YP21 |
| NCBI GenInfo Identifier: | 56713254 |
| NCBI Gene ID: | 56267 |
| NCBI Accession: | NP_001008661.1 |
| UniProt Secondary Accession: | Q6YP21,O95335, Q5JS27, Q5T9T7, Q5T9T8, Q6AI27, Q6ICW1 Q9BVY5, B3KQ13 |
| UniProt Related Accession: | Q6YP21 |
| Molecular Weight: | 67.4 kDa |
| NCBI Full Name: | kynurenine--oxoglutarate transaminase 3 isoform 1 |
| NCBI Synonym Full Names: | cysteine conjugate-beta lyase 2 |
| NCBI Official Symbol: | CCBL2Â Â |
| NCBI Official Synonym Symbols: | KAT3; KATIIIÂ Â |
| NCBI Protein Information: | kynurenine--oxoglutarate transaminase 3 |
| UniProt Protein Name: | Kynurenine--oxoglutarate transaminase 3 |
| UniProt Synonym Protein Names: | Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13); Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase (EC:2.6.1.63); Kynurenine--oxoglutarate transaminase III |
| Protein Family: | Kynurenine--oxoglutarate transaminase |
| UniProt Gene Name: | CCBL2Â Â |
| UniProt Entry Name: | KAT3_HUMAN |
