KYAT3 Antibody (PACO36714)
- SKU:
- PACO36714
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KYAT3 Antibody (PACO36714)
The KYAT3 Polyclonal Antibody (PACO36714) is a vital tool for researchers studying the KYAT3 protein, an enzyme involved in the metabolism of kynurenine, a key molecule in the tryptophan degradation pathway. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it a reliable choice for Western blot applications.KYAT3, also known as kynurenine aminotransferase 3, plays a crucial role in regulating the levels of kynurenine, which has been implicated in various neurological disorders, immune responses, and cancer progression.
By targeting KYAT3 with this antibody, researchers can investigate its role in these pathways and potentially identify new therapeutic targets for diseases such as neurodegenerative disorders, autoimmune diseases, and cancers.This KYAT3 Polyclonal Antibody is a valuable tool for researchers looking to deepen their understanding of the kynurenine pathway and its implications in health and disease. Its specificity and reliability in detecting KYAT3 make it an essential component in studies aimed at uncovering the intricacies of this critical metabolic pathway.
| Antibody Name: | KYAT3 Antibody (PACO36714) |
| Antibody SKU: | PACO36714 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Kynurenine--oxoglutarate transaminase 3 protein (1-454AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO36714 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO36714 at dilution of 1:100. |
| Background: | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid, (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond By similarity. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). |
| Synonyms: | Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III), KYAT3, CCBL2 KAT3 |
| UniProt Protein Function: | CCBL2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Lyase; EC 2.6.1.63; EC 2.6.1.7; EC 4.4.1.13; TransferaseChromosomal Location of Human Ortholog: 1p22.2Cellular Component: mitochondrionMolecular Function: cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; protein homodimerization activity; pyridoxal phosphate bindingBiological Process: 2-oxoglutarate metabolic process; amino acid metabolic process; biosynthetic process; tryptophan catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q6YP21 |
| NCBI GenInfo Identifier: | 56713254 |
| NCBI Gene ID: | 56267 |
| NCBI Accession: | NP_001008661.1 |
| UniProt Secondary Accession: | Q6YP21,O95335, Q5JS27, Q5T9T7, Q5T9T8, Q6AI27, Q6ICW1 Q9BVY5, B3KQ13 |
| UniProt Related Accession: | Q6YP21 |
| Molecular Weight: | 67.4 kDa |
| NCBI Full Name: | kynurenine--oxoglutarate transaminase 3 isoform 1 |
| NCBI Synonym Full Names: | cysteine conjugate-beta lyase 2 |
| NCBI Official Symbol: | CCBL2Â Â |
| NCBI Official Synonym Symbols: | KAT3; KATIIIÂ Â |
| NCBI Protein Information: | kynurenine--oxoglutarate transaminase 3 |
| UniProt Protein Name: | Kynurenine--oxoglutarate transaminase 3 |
| UniProt Synonym Protein Names: | Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13); Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase (EC:2.6.1.63); Kynurenine--oxoglutarate transaminase III |
| Protein Family: | Kynurenine--oxoglutarate transaminase |
| UniProt Gene Name: | CCBL2Â Â |
| UniProt Entry Name: | KAT3_HUMAN |
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