Ku80 Rabbit Monoclonal Antibody (CAB12338)
- SKU:
- CAB12338
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Ku80 Rabbit Monoclonal Antibody |
SKU: | CAB12338 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 633-732 of human Ku80 (P13010). |
Sequence: | MKSI DCIR AFRE EAIK FSEE QRFN NFLK ALQE KVEI KQLN HFWE IVVQ DGIT LITK EEAS GSSV TAEE AKKF LAPK DKPS GDTA AVFE EGGD VDDL LDMI |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; Ku80 |
Positive Sample: | HeLa,A-549,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, nucleolus. |
Calculated MW: | 83kDa |
Observed MW: | 86kDa |
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Purification Method: | Affinity purification |
Gene ID: | 7520 |
Clone Number: | ARC0706 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |