The Ku80 Polyclonal Antibody is a valuable tool for research into Ku80, a key protein involved in DNA repair processes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to Ku80, researchers can easily detect and analyze this important protein in a variety of cell types, making it ideal for studies in genetics, cancer research, and molecular biology.Ku80 is a critical component of the DNA-dependent protein kinase complex that plays a crucial role in repairing DNA double-strand breaks.
Understanding the function and regulation of Ku80 is essential for unraveling the mechanisms underlying genome stability, mutagenesis, and cancer development. This antibody provides researchers with a powerful tool to investigate the role of Ku80 in cellular processes and disease pathology, ultimately contributing to advancements in the field of DNA repair and cancer biology.
Product Name:
Ku80 Polyclonal Antibody
SKU:
CAB24867
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 543-732 of mouse Ku80 (NP_033559.2).
Predicted to enable several functions, including nucleic acid binding activity; protein C-terminus binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
Purification Method:
Affinity purification
Gene ID:
22596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ku80 Rabbit pAb (CAB24867) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
