The KU70 Rabbit Monoclonal Antibody is a high-quality research tool designed for the detection of the KU70 protein, which plays a crucial role in DNA repair and maintenance. This antibody is produced in rabbits and is highly specific to human samples, making it ideal for use in various research applications, including Western blotting and immunofluorescence.The KU70 protein is a key component of the DNA-dependent protein kinase complex, which is involved in the repair of DNA double-strand breaks. Dysregulation of KU70 has been linked to genetic instability and the development of various diseases, including cancer.
Therefore, this antibody is an essential tool for studying the function and regulation of KU70 in cellular processes and disease pathways.With its high sensitivity and specificity, the KU70 Rabbit Monoclonal Antibody is a valuable asset for researchers working in the fields of molecular biology, genetics, and cancer research. By facilitating the detection and analysis of KU70 protein expression, this antibody contributes to our understanding of DNA repair mechanisms and their implications in human health and disease.
Product Name:
Ku70 Rabbit Monoclonal Antibody
SKU:
CAB11223
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-609 of human Ku70 (P12956).
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Purification Method:
Affinity purification
Gene ID:
2547
Clone Number:
ARC0551
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ku70 Rabbit mAb (CAB11223) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
