The KSR1 Polyclonal Antibody (CAB15118) is a valuable tool for researchers studying KSR1, a kinase suppressor of Ras-1 involved in cell signaling pathways and cancer development. Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for Western blot applications, allowing for the detection and analysis of KSR1 protein in various cell types.KSR1 is known for its role in regulating the Ras-MAPK pathway, which is crucial for cell growth, differentiation, and survival. Dysregulation of this pathway is commonly observed in cancer, making KSR1 a potential target for cancer therapy research.
By studying KSR1 expression and function, researchers can gain insights into the molecular mechanisms underlying cancer progression and potentially identify new therapeutic targets.With its specificity and sensitivity, the KSR1 Polyclonal Antibody is an essential tool for investigating the role of KSR1 in cancer biology and signaling pathways. Its applications extend to immunohistochemistry, immunofluorescence, and other research techniques aimed at understanding the functions of KSR1 in normal and pathological conditions.
Product Name:
KSR1 Rabbit Polyclonal Antibody
SKU:
CAB15118
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 320-420 of human KSR1 (NP_055053.1).
Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer.
Purification Method:
Affinity purification
Gene ID:
8844
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KSR1 Rabbit pAb (CAB15118) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
