The KRTAP3-3 Antibody (PAC041278) is a polyclonal antibody specifically designed for research involving KRTAP3-3, a member of the keratin-associated protein family essential for hair structure and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting.KRTAP3-3 plays a crucial role in the development and maintenance of hair, as it interacts with keratin proteins to provide structural support and strength. Understanding the function and regulation of KRTAP3-3 is essential for studies focused on hair biology, hair disorders, and cosmetic research.
By utilizing the KRTAP3-3 Antibody (PAC041278), researchers can effectively detect and analyze the presence of KRTAP3-3 in different cellular contexts, paving the way for advancements in the fields of dermatology, hair biology, and cosmetic science. Its specificity and versatility make it an invaluable tool for studies aimed at unraveling the intricate mechanisms underlying hair growth and maintenance.
Antibody Name:
KRTAP3-3 Antibody (PACO41278)
Antibody SKU:
PACO41278
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Keratin-associated protein 3-3 protein (1-98AA)
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Synonyms:
Keratin-associated protein 3-3 (High sulfur keratin-associated protein 3.3) (Keratin-associated protein 3.3), KRTAP3-3, KAP3.3 KRTAP3.3
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
