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KRTAP3-1 Antibody (PACO40514)

SKU:
PACO40514
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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KRTAP3-1 Antibody (PACO40514)

The KRTAP3-1 Antibody (PAC040514) is a polyclonal antibody designed for research involving KRTAP3-1, a protein associated with hair formation and development. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.KRTAP3-1, a keratin-associated protein, is known for its role in maintaining the structure and function of hair fibers. Studies have shown that mutations in KRTAP3-1 gene can lead to abnormalities in hair morphology.

The KRTAP3-1 Antibody enables detection and analysis of KRTAP3-1 protein expression in different cell types, offering valuable insights into hair biology and potential implications for hair-related conditions.This antibody is a valuable tool for researchers studying hair biology, dermatology, and related fields. By understanding the function and regulation of KRTAP3-1, researchers can gain further insights into hair development, disorders, and potential therapeutic targets for hair-related conditions.

Antibody Name:KRTAP3-1 Antibody (PACO40514)
Antibody SKU:PACO40514
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Keratin-associated protein 3-1 protein (2-98AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Synonyms:Keratin-associated protein 3-1 (High sulfur keratin-associated protein 3.1) (Keratin-associated protein 3.1), KRTAP3-1, KAP3.1 KRTAP3.1
UniProt Protein Function:KRTAP3-1: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. Belongs to the KRTAP type 3 family.Chromosomal Location of Human Ortholog: 17q21.2Cellular Component: keratin filamentMolecular Function: structural molecule activity
UniProt Protein Details:
NCBI Summary:This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYR8
NCBI GenInfo Identifier:13994362
NCBI Gene ID:83896
NCBI Accession:NP_114164.1
UniProt Secondary Accession:Q9BYR8,Q14DM4
UniProt Related Accession:Q9BYR8
Molecular Weight:10,539 Da
NCBI Full Name:keratin-associated protein 3-1
NCBI Synonym Full Names:keratin associated protein 3-1
NCBI Official Symbol:KRTAP3-1  
NCBI Official Synonym Symbols:KAP3.1; KRTAP3.1  
NCBI Protein Information:keratin-associated protein 3-1; high sulfur keratin-associated protein 3.1
UniProt Protein Name:Keratin-associated protein 3-1
UniProt Synonym Protein Names:High sulfur keratin-associated protein 3.1; Keratin-associated protein 3.1
Protein Family:Keratin-associated protein
UniProt Gene Name:KRTAP3-1  
UniProt Entry Name:KRA31_HUMAN

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