The KRT7 Polyclonal Antibody (CAB12004) is a valuable tool for researchers studying keratin 7, a type II cytokeratin protein expressed in epithelial cells. This polyclonal antibody is produced in rabbits and is highly reactive with human samples, making it suitable for a variety of research applications.Keratin 7 is involved in maintaining the structural integrity of epithelial tissues, providing support and protection to cells. Abnormal expression of keratin 7 has been linked to various diseases, including cancers of the breast, ovary, and lung, making it a target of interest for cancer research.
With its specificity for keratin 7, the CAB12004 antibody enables researchers to detect and analyze the protein in different cell types and tissue samples. Its validation for use in Western blot applications ensures reliable and accurate results, making it a valuable tool for studies focused on epithelial biology, cancer research, and other related fields.
Product Name:
Cytokeratin 7 (KRT7) Rabbit Polyclonal Antibody
SKU:
CAB12004
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human Cytokeratin 7 (KRT7) (NP_005547.3).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.
Purification Method:
Affinity purification
Gene ID:
3855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Cytokeratin 7 (KRT7) Rabbit pAb (CAB12004) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
