The KRT7 Monoclonal Antibody (PAC020973) is a valuable tool for researchers investigating the role of keratin 7 (KRT7) in various cellular processes. KRT7 is a type II cytokeratin that is expressed in simple epithelia and many types of glandular epithelia. This antibody, produced in mice, is highly specific to human KRT7 protein and is ideal for use in immunohistochemistry (IHC) and immunofluorescence (IF) applications.KRT7 is an important biomarker for identifying epithelial cells in tissues and has been implicated in the progression of certain cancers, such as breast and ovarian cancer.
The KRT7 Monoclonal Antibody allows for the detection and visualization of KRT7 expression in a variety of tissue samples, aiding researchers in understanding its role in cancer development and metastasis.With its high specificity and sensitivity in detecting KRT7, this antibody is a valuable tool for studies in oncology, cell biology, and tissue pathology. By targeting KRT7, researchers can further explore its function and potential as a diagnostic marker or therapeutic target in cancer research.
Antibody Name:
KRT7 Antibody (PACO20973)
Antibody SKU:
PACO20973
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human KRT7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20973(KRT7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20973(KRT7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.
Synonyms:
keratin 7, type II
UniProt Protein Function:
K7: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
keratin, type II cytoskeletal 7; CK-7; keratin-7; sarcolectin; cytokeratin 7; cytokeratin-7; type-II keratin Kb7; type II mesothelial keratin K7; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7
