The KRT7 Antibody (PAC020972) is a valuable tool for researchers studying the keratin protein KRT7, which is involved in maintaining the structural integrity of epithelial cells. This polyclonal antibody, produced in rabbits, has high reactivity with human samples and is suitable for use in Western blot applications. By binding to the KRT7 protein, this antibody allows for accurate detection and analysis in a variety of cell types.KRT7 is a key component of intermediate filaments found in epithelial tissues, where it plays a role in cell migration, adhesion, and signaling. Dysregulation of KRT7 expression has been implicated in various diseases, including cancers of the gastrointestinal tract and bile ducts.
Studying the function of KRT7 is essential for understanding its role in normal cellular processes and disease progression.Researchers in fields such as cell biology, cancer research, and molecular biology will find the KRT7 Antibody to be a valuable tool for investigating the function of KRT7 in different cellular contexts. Its specificity and reliability make it a trusted choice for studies aimed at unraveling the complex role of KRT7 in health and disease.
Antibody Name:
KRT7 Antibody (PACO20972)
Antibody SKU:
PACO20972
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human KRT7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20972(KRT7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20972(KRT7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.
Synonyms:
keratin 7, type II
UniProt Protein Function:
K7: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
keratin, type II cytoskeletal 7; CK-7; keratin-7; sarcolectin; cytokeratin 7; cytokeratin-7; type-II keratin Kb7; type II mesothelial keratin K7; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7
