KRT6A Monoclonal Antibody (MACO0054)
- SKU:
- MACO0054
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
Anti-KRT6A Antibody (MACO0054)
The KRT6A Monoclonal Antibody (MACO0054) is a valuable tool for researchers studying Keratin 6A, a protein that plays a key role in the structure and function of epithelial cells. This antibody, generated in mice, specifically targets KRT6A and is optimized for use in various applications such as Western blot, immunofluorescence, and immunohistochemistry.Keratin 6A is a type II cytokeratin expressed in epithelial tissues, particularly in the skin, hair, and nails. Dysregulation of KRT6A has been associated with various skin disorders, including psoriasis and epithelial cancers.
By targeting KRT6A, researchers can investigate its role in cell differentiation, proliferation, and disease pathogenesis.Whether studying skin biology, cancer development, or tissue regeneration, the KRT6A Monoclonal Antibody (MACO0054) provides a reliable tool for detecting and analyzing KRT6A expression in different experimental settings. Its specificity and sensitivity make it a valuable asset for advancing research in dermatology, oncology, and regenerative medicine.
| Product Name: | Anti-KRT6A Antibody |
| Product Sku: | MACO0054 |
| Size: | 50ug |
| Host Species: | Mouse |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic Peptide |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Clonality: | Monoclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | |
| Synonyms: | Keratin type II cytoskeletal 6A/B/C |
 | Western blot analysis of 1) Hela, 2) HepG2, diluted at 1:2000. |
| UniProt Protein Function: | K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: membrane; keratin filament; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation Disease: Pachyonychia Congenita 3 |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P02538 |
| NCBI GenInfo Identifier: | 1346344 |
| NCBI Gene ID: | 3853 |
| NCBI Accession: | P02538.3 |
| UniProt Related Accession: | P02538 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Keratin, type II cytoskeletal 6A |
| NCBI Synonym Full Names: | keratin 6A |
| NCBI Official Symbol: | KRT6AÂ Â |
| NCBI Official Synonym Symbols: | K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6DÂ Â |
| NCBI Protein Information: | keratin, type II cytoskeletal 6A |
| UniProt Protein Name: | Keratin, type II cytoskeletal 6A |
| UniProt Synonym Protein Names: | Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Allergen: Hom s 5 |
| UniProt Gene Name: | KRT6AÂ Â |
| UniProt Entry Name: | K2C6A_HUMAN |
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