The KRT40 Antibody (PAC014061) is a polyclonal antibody designed for research involving KRT40, a keratin protein involved in the structural framework of epithelial cells. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.KRT40 is a type I keratin protein that is predominantly expressed in the hair follicles, specifically in the inner root sheath. Its role in hair growth and maintenance makes it a relevant target for studies in dermatology and hair biology.
The KRT40 antibody enables the detection and analysis of KRT40 expression in different cell types, providing valuable insights into its function and potential implications in various skin disorders.Understanding the expression and function of KRT40 is essential for advancing research in skin biology, hair growth, and dermatological conditions. The KRT40 Antibody provides researchers with a reliable tool to investigate the role of KRT40 in physiological processes and diseases related to the skin and hair follicles.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14061(KRT40 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Lovo cells, Primary antibody: PACO14061(KRT40 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14061(KRT40 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the type I (acid, c) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21.
Synonyms:
keratin 40
UniProt Protein Function:
May play a role in late hair differentiation.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
