KRT38/KRT37 Antibody (PACO22755)
- SKU:
- PACO22755
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KRT38/KRT37 Antibody (PACO22755)
The KRT38/KRT37 Antibody (PAC02755) is a polyclonal antibody specifically designed for research involving the keratin proteins KRT38 and KRT37. These intermediate filament proteins are essential components of the cytoskeleton in epithelial cells, providing structural support and integrity. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. It binds to the KRT38 and KRT37 proteins, allowing for their detection and analysis in various cell types. Keratins play a crucial role in maintaining the structural integrity of epithelial tissues, protecting against mechanical stress and providing resistance to damage.
Dysregulation of keratin expression has been implicated in various skin disorders, genetic diseases, and cancers. By studying the expression and function of KRT38 and KRT37 using this antibody, researchers can gain insights into the role of keratins in normal physiological processes and disease pathology. This antibody is a valuable tool for studies in cell biology, dermatology, and oncology, providing a better understanding of the complex dynamics of keratin proteins in health and disease.
| Antibody Name: | KRT38/KRT37 Antibody (PACO22755) |
| Antibody SKU: | PACO22755 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human KRT37/38. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using KRT37/38 antibody. |
| Background: | The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. |
| Synonyms: | Keratin; type I cuticular Ha8; Hair keratin; type I Ha8; Keratin-38 |
| UniProt Protein Function: | KRT38: Belongs to the intermediate filament family |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: intermediate filament Molecular Function:protein binding; structural molecule activity |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76015 |
| NCBI GenInfo Identifier: | 15431318 |
| NCBI Gene ID: | 8687 |
| NCBI Accession: | NP_006762.3 |
| UniProt Secondary Accession: | O76015,Q6A164, A2RRM5, |
| UniProt Related Accession: | O76015 |
| Molecular Weight: | 50,480 Da |
| NCBI Full Name: | keratin, type I cuticular Ha8 |
| NCBI Synonym Full Names: | keratin 38, type I |
| NCBI Official Symbol: | KRT38Â Â |
| NCBI Official Synonym Symbols: | HA8; hHa8; KRTHA8Â Â |
| NCBI Protein Information: | keratin, type I cuticular Ha8 |
| UniProt Protein Name: | Keratin, type I cuticular Ha8 |
| UniProt Synonym Protein Names: | Hair keratin, type I Ha8; Keratin-38; K38 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT38Â Â |
| UniProt Entry Name: | KRT38_HUMAN |
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