KRT20 Antibody (PACO20974)
- SKU:
- PACO20974
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KRT20 Antibody (PACO20974)
The KRT20 Polyclonal Antibody (PAC020974) is a valuable tool for researchers studying KRT20, a protein involved in maintaining the structure and function of epithelial cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. It specifically targets the KRT20 protein, allowing for precise detection and analysis in a variety of cell types.KRT20, also known as keratin 20, is a critical component of the cytoskeleton in epithelial cells, providing structural support and integrity to tissues like the colon and gastrointestinal tract.
Dysregulation of KRT20 has been implicated in various diseases, including colorectal cancer and inflammatory bowel disease. By studying the expression and function of KRT20, researchers can gain insights into the pathogenesis of these conditions and potentially identify novel therapeutic targets.Overall, the KRT20 Polyclonal Antibody is a valuable tool for investigating the role of KRT20 in epithelial cell biology and disease pathology. Its high specificity and sensitivity make it a reliable choice for researchers conducting immunology and cancer research studies.
| Antibody Name: | KRT20 Antibody (PACO20974) |
| Antibody SKU: | PACO20974 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human KRT20 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20974(KRT20 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20974(KRT20 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acid, c proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. |
| Synonyms: | keratin 20, type I |
| UniProt Protein Function: | Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine |
| UniProt Protein Details: | By similarity. Ref.4 Ref.8 Subunit structure: Heterotetramer of two type I and two type II keratins. Associates with KRT8. Subcellular location: Cytoplasm Ref.6 Ref.7. Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. Ref.6 Ref.7 Developmental stage: First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative. Ref.1 Post-translational modification: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury By similarity.Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. Ref.4 Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Sequence similarities: Belongs to the intermediate filament family. |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35900 |
| NCBI GenInfo Identifier: | 547750 |
| NCBI Gene ID: | 54474 |
| NCBI Accession: | P35900.1 |
| UniProt Secondary Accession: | P35900,B2R6W7, |
| UniProt Related Accession: | P35900 |
| Molecular Weight: | |
| NCBI Full Name: | Keratin, type I cytoskeletal 20 |
| NCBI Synonym Full Names: | keratin 20 |
| NCBI Official Symbol: | KRT20Â Â |
| NCBI Official Synonym Symbols: | K20; CD20; CK20; CK-20; KRT21Â Â |
| NCBI Protein Information: | keratin, type I cytoskeletal 20; keratin-20; protein IT; cytokeratin 20; cytokeratin-20 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 20 |
| UniProt Synonym Protein Names: | Cytokeratin-20; CK-20; Keratin-20; K20; Protein IT |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT20Â Â |
| UniProt Entry Name: | K1C20_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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