The KRT17 Polyclonal Antibody (CAB0123) is a valuable tool for researchers studying keratin 17 (KRT17), a type I keratin protein that is primarily expressed in hair follicles, nail beds, and sweat glands. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in Western blot applications.KRT17 is involved in maintaining the structural integrity of epithelial cells and is associated with various diseases, including cancer and skin disorders. By targeting KRT17, researchers can investigate its role in cell differentiation, proliferation, and migration, making this antibody ideal for studies in cell biology and dermatology.
Understanding the function of KRT17 is essential for developing targeted therapies for conditions where its dysregulation plays a role, such as in cancer progression or skin diseases. The KRT17 Polyclonal Antibody provides researchers with a reliable tool for detecting and analyzing KRT17 levels in different cell types, allowing for deeper insights into its biological significance.
Product Name:
Cytokeratin 17 (KRT17) Rabbit Polyclonal Antibody
SKU:
CAB0123
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 133-432 of human Cytokeratin 17 (KRT17) (NP_000413.1).
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
Purification Method:
Affinity purification
Gene ID:
3872
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cytokeratin 17 (KRT17) antibody (CAB0123) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
