The KRT17 Polyclonal Antibody (PAC027853) is a valuable tool for researchers exploring the role of KRT17 in cell biology and disease. KRT17, a member of the keratin protein family, is involved in the structural integrity of epithelial cells and is frequently dysregulated in various cancers.This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting and immunohistochemistry applications. By targeting the KRT17 protein, this antibody enables precise detection and analysis of KRT17 expression in a wide range of cell types and tissues.Studies have shown that aberrant expression of KRT17 is associated with tumor progression and metastasis in several cancer types, highlighting its potential as a biomarker for cancer diagnosis and prognosis.
Furthermore, KRT17 has been linked to the regulation of cell migration and invasion, making it a promising target for therapeutic interventions aimed at inhibiting cancer metastasis.By utilizing the KRT17 Polyclonal Antibody, researchers can gain valuable insights into the biological functions of KRT17 and its implications in cancer biology, paving the way for the development of novel diagnostic and therapeutic strategies for cancer treatment.
Antibody Name:
KRT17 Antibody (PACO27853)
Antibody SKU:
PACO27853
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Bovine
Immunogen:
Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA)
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-α in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Synonyms:
Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17), KRT17
UniProt Protein Function:
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
