The KRT16 Polyclonal Antibody (CAB7493) is a specialized tool designed for research studies involving Keratin 16 (KRT16), a type I cytokeratin protein primarily expressed in hair follicles, nail beds, and other epidermal tissues. This antibody, produced through rabbit immunization, exhibits high specificity and sensitivity when used with human samples, making it an excellent choice for various experimental applications such as Western blot and immunohistochemistry.KRT16 is a crucial component of the cytoskeleton in epithelial cells, providing structural support and integrity to the skin and its appendages. Dysregulation of KRT16 expression has been linked to various dermatological disorders and cancers, highlighting its importance in skin biology and disease pathogenesis.
By utilizing the KRT16 Polyclonal Antibody, researchers can investigate the distribution, localization, and functions of KRT16 in different cell types and tissues, advancing our understanding of skin development, homeostasis, and pathology.Furthermore, exploring the role of KRT16 in skin diseases, wound healing, and cancer progression may lead to the development of targeted therapies and diagnostic markers for improving patient outcomes. The KRT16 Polyclonal Antibody is a valuable tool for investigating the intricate mechanisms of epidermal biology and disease, paving the way for innovative discoveries in dermatology and oncology research.
Product Name:
KRT16 Rabbit Polyclonal Antibody
SKU:
CAB7493
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-430 of human Cytokeratin 16 (KRT16) (NP_005548.2).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Purification Method:
Affinity purification
Gene ID:
3868
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 16 (KRT16) Rabbit pAb (CAB7493) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
