KRT14/KRT17 Antibody (PACO07457)
- SKU:
- PACO07457
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KRT14/KRT17 Antibody (PACO07457)
The KRT14/KRT17 Antibody (PACO07457) is a highly specific and sensitive tool for researchers studying keratin 14 (KRT14) and keratin 17 (KRT17) proteins. Keratins are key structural proteins found in epithelial cells, providing them with strength and resilience. This polyclonal antibody, raised in rabbits, specifically targets KRT14 and KRT17, and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.KRT14 and KRT17 are commonly associated with epithelial cells in the skin, hair follicles, and nails, playing important roles in maintaining tissue integrity and protecting against mechanical stress.
Dysregulation of these keratins has been linked to various skin disorders, including epidermolysis bullosa and psoriasis, as well as certain types of cancer. The KRT14/KRT17 Antibody enables precise detection and analysis of these proteins, facilitating research into the mechanisms underlying these conditions and potential therapeutic targets.By utilizing the KRT14/KRT17 Antibody in your experiments, you can gain valuable insights into the functions and dysregulation of KRT14 and KRT17 in different cellular contexts, advancing our understanding of skin biology, disease mechanisms, and potential treatment strategies.
| Antibody Name: | KRT14/KRT17 Antibody (PACO07457) |
| Antibody SKU: | PACO07457 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:10000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide from AA range: 261-310 |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HEPG2 cells using Antibody diluted at 1000. |
| Synonyms: | KRT14 |
| UniProt Protein Function: | K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: epidermis development; hemidesmosome assembly; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; hair cycle; aging Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type |
| NCBI Summary: | This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02533 |
| NCBI GenInfo Identifier: | 229463044 |
| NCBI Gene ID: | 3861 |
| NCBI Accession: | P02533.4 |
| UniProt Secondary Accession: | P02533,P08779, |
| UniProt Related Accession: | P02533 |
| Molecular Weight: | ~ 52kDa |
| NCBI Full Name: | Keratin, type I cytoskeletal 14 |
| NCBI Synonym Full Names: | keratin 14 |
| NCBI Official Symbol: | KRT14Â Â |
| NCBI Official Synonym Symbols: | K14; NFJ; CK14; EBS3; EBS4Â Â |
| NCBI Protein Information: | keratin, type I cytoskeletal 14 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 14 |
| UniProt Synonym Protein Names: | Cytokeratin-14; CK-14; Keratin-14; K14 |
| Protein Family: | Putative outer capsid protein |
| UniProt Gene Name: | KRT14Â Â |
| UniProt Entry Name: | K1C14_HUMAN |
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