The KRT14 Polyclonal Antibody (CAB15069) is a valuable tool for researchers studying keratin 14, a critical protein involved in the structural integrity of epithelial cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KRT14 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations related to epithelial biology and skin disorders.Keratin 14 is a key component of the cytoskeleton in epithelial cells, providing structural support and resilience to various tissues, particularly in the skin.
Dysregulation of KRT14 expression is associated with conditions such as skin disorders, cancers, and developmental abnormalities. Therefore, studying the role of KRT14 using this polyclonal antibody can offer valuable insights into disease mechanisms and potential therapeutic targets.By utilizing the KRT14 Polyclonal Antibody in research, scientists can further our understanding of epithelial biology and potentially uncover new strategies for tackling various skin conditions and diseases related to abnormal keratin expression.
Product Name:
Cytokeratin 14 (KRT14) Rabbit Polyclonal Antibody
SKU:
CAB15069
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 371-470 of human Cytokeratin 14 (KRT14) (NP_000517.3).
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.
Purification Method:
Affinity purification
Gene ID:
3861
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 14 (Cytokeratin 14 (KRT14)) Rabbit pAb (CAB15069) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
