The KRT13 Polyclonal Antibody (CAB7697) is a valuable tool for researchers studying keratin 13 (KRT13), a type I keratin protein found in epithelial cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to KRT13, this antibody enables researchers to detect and analyze the expression of this protein in various cell types.KRT13 is known for its role in maintaining the structural integrity of epithelial cells, particularly in tissues such as the oral mucosa, esophagus, and female genital tract.
Aberrant expression of KRT13 has been linked to several diseases, including oral cancer and certain skin disorders. Therefore, understanding the regulation and functions of KRT13 is vital for uncovering potential therapeutic targets for these conditions.By using the KRT13 Polyclonal Antibody, researchers can gain valuable insights into the role of KRT13 in normal tissue development and disease progression. This antibody is a valuable tool for studies in dermatology, oncology, and regenerative medicine, providing researchers with a deeper understanding of the functions of KRT13 in health and disease.
Product Name:
Cytokeratin 13 (KRT13) Rabbit Polyclonal Antibody
SKU:
CAB7697
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 269-458 of human Cytokeratin 13 (Cytokeratin 13 (KRT13)) (NP_705694.2).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described.
Purification Method:
Affinity purification
Gene ID:
3860
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cytokeratin 13 (Cytokeratin 13 (KRT13)) antibody (CAB7697) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
