The KRT13 Polyclonal Antibody (CAB16393) is a valuable tool for researchers studying keratin 13 (KRT13), a protein that is predominantly found in the epithelial cells of various tissues, including the skin and mucous membranes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for immunohistochemistry and immunofluorescence applications.KRT13 is involved in maintaining the structural integrity of epithelial cells and is essential for normal cell function and differentiation. Abnormalities in KRT13 expression have been linked to several medical conditions, including skin disorders and certain types of cancer.
By using the KRT13 Polyclonal Antibody, researchers can accurately detect and analyze the presence of KRT13 in different tissue samples, aiding in the investigation of its role in disease pathology and potential therapeutic targets.Overall, the KRT13 Polyclonal Antibody is a valuable tool for studies in dermatology, oncology, and cell biology, providing researchers with the means to delve deeper into the functions and implications of KRT13 in various physiological and pathological processes.
Product Name:
Cytokeratin 13 (KRT13) Rabbit Polyclonal Antibody
SKU:
CAB16393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 269-458 of human Cytokeratin 13 (Cytokeratin 13 (KRT13)) (NP_705694.2).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described.
Purification Method:
Affinity purification
Gene ID:
3860
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using Cytokeratin 13 (Cytokeratin 13 (KRT13)) Rabbit pAb (CAB16393) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
