The Kremen2 Polyclonal Antibody (CAB16202) is a valuable tool for researchers studying the function of Kremen2, a cell surface protein involved in various signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Kremen2 protein, this antibody allows for the accurate detection and analysis of Kremen2 expression in diverse cell types, making it ideal for investigations in the fields of cell biology and developmental biology.
Kremen2 is known to interact with Wnt signaling proteins and play a role in the regulation of cell proliferation, differentiation, and migration. Its involvement in these crucial cellular processes makes it a promising target for research on developmental disorders, cancer, and other diseases. By studying the function of Kremen2 using this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
KREMEN2 Rabbit Polyclonal Antibody
SKU:
CAB16202
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1).
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
79412
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KREMEN2 Rabbit pAb (CAB16202) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
