The Kremen Protein 1 Polyclonal Antibody (CAB10507) is a valuable tool for researchers studying the Kremen Protein 1, a crucial regulator of the Wnt signaling pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the Kremen Protein 1, researchers can accurately detect and analyze this protein in various cell types, making it an essential component in studies related to developmental biology and cancer research.
The Kremen Protein 1 is known for its role in modulating Wnt signaling, a pathway involved in cell proliferation, differentiation, and embryonic development. Dysregulation of this pathway has been implicated in various diseases, including cancer and developmental disorders. By investigating the function and regulation of Kremen Protein 1, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
KREMEN1 Rabbit Polyclonal Antibody
SKU:
CAB10507
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human KREMEN1 (NP_001034659.2).
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2.
Purification Method:
Affinity purification
Gene ID:
83999
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KREMEN1 antibody (CAB10507) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
