The KRCC1 Polyclonal Antibody (PAC040850) is a specialized tool for researchers studying KRCC1, a key component involved in chromosome segregation during cell division. This antibody, produced through immunization of rabbits, exhibits high reactivity specifically with human samples and is validated for use in Western blot assays. By binding to the KRCC1 protein, it enables accurate visualization and analysis in a variety of cell types, making it an essential reagent for studies in cell biology, cancer research, and developmental biology.KRCC1, also known as Kinesin-related motor protein-like component 1, plays a crucial role in ensuring the faithful distribution of chromosomes to daughter cells during mitosis.
Dysregulation of KRCC1 has been implicated in chromosomal instability, a hallmark of cancer development and progression. Understanding the function and regulation of KRCC1 is essential for uncovering mechanisms underlying chromosomal segregation errors and their implications in disease states.With its specificity and reliability, the KRCC1 Polyclonal Antibody (PAC040850) offers researchers a valuable tool for investigating the role of KRCC1 in cellular processes, disease pathways, and potential therapeutic targets. Expand your knowledge and advance your research with this essential antibody reagent.
Antibody Name:
KRCC1 Antibody (PACO40850)
Antibody SKU:
PACO40850
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Lysine-rich coiled-coil protein 1 protein (1-259AA)
Immunofluorescence staining of A549 cells with PACO40850 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
mitophagy in response to mitochondrial depolarization
Synonyms:
Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein 2), KRCC1, CHBP2
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
