The KPNA5 Polyclonal Antibody (CAB7331) is a vital tool for research involving the KPNA5 protein, which plays a crucial role in nucleocytoplasmic transport. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the KPNA5 protein, researchers can detect and analyze its expression in various cell types, providing valuable insights into cellular transport mechanisms.KPNA5, also known as Importin alpha-6, is essential for the transportation of proteins into the nucleus, thereby regulating gene expression and cellular functions.
Dysregulation of KPNA5 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular homeostasis. Investigating the role of KPNA5 can lead to a better understanding of disease mechanisms and potential therapeutic targets related to nucleocytoplasmic transport pathways. This antibody is an excellent tool for studies in molecular biology, cell biology, and disease research.
Product Name:
KPNA5 Rabbit Polyclonal Antibody
SKU:
CAB7331
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KPNA5 (NP_002260.2).
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
Purification Method:
Affinity purification
Gene ID:
3841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KPNA5 antibody (CAB7331) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 20s.
