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KPNA2 Rabbit Monoclonal Antibody (CAB5012)

SKU:
CAB5012
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IPOA1
QIP2
RCH1
SRP1-alpha
SRP1alpha
Research Area:
Immunology
  • Immunology Antibodies 3 Anti-KPNA2 Antibody CAB5012
  • Immunology Antibodies 3 Anti-KPNA2 Antibody CAB5012
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:KPNA2 Rabbit Monoclonal Antibody
SKU:CAB5012
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KPNA2 (P52292).
Sequence:MSTN ENAN TPAA RLHR FKNK GKDS TEMR RRRI EVNV ELRK AKKD DQML KRRN VSSF PDDA TSPL QENR NNQG TVNW SVDD IVKG INSS NVEN QLQA TQAA
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha; KPNA2
Positive Sample:A549,NIH/3T3,C6,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:58kDa
Observed MW:58kDa

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3838
Clone Number:ARC1227
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using KPNA2 Rabbit mAb (CAB5012) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.

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