KPNA2 Rabbit Polyclonal Antibody (CAB1623)
- SKU:
- CAB1623
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | KPNA2 Rabbit Polyclonal Antibody |
SKU: | CAB1623 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2 (NP_002257.1). |
Sequence: | MSTN ENAN TPAA RLHR FKNK GKDS TEMR RRRI EVNV ELRK AKKD DQML KRRN VSSF PDDA TSPL QENR NNQG TVNW SVDD IVKG INSS NVEN QLQA TQAA RKLL SREK QPPI DNII RAGL IPKF VSFL GRTD CSPI QFES AWAL TNIA SGTS EQTK AVVD GGAI PAFI SLLA SPHA HISE QAVW ALGN IAGD GSVF RDLV IKYG AVDP LLAL LAVP DMSS LACG YLRN LTWT LSNL CRNK NPAP PIDA VEQI LPTL VRLL HHDD PEVL ADTC WAIS YLTD GPNE RIGM VV |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha; KPNA2 |
Positive Sample: | MCF7,PC-3,U-251MG,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 58kDa |
Observed MW: | 55kDa |
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3838 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |