The KPNA2 Polyclonal Antibody (CAB1623) is a valuable tool for researchers studying KPNA2, a protein involved in nucleocytoplasmic transport. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the KPNA2 protein, researchers can easily detect and analyze KPNA2 in various cell types, making it an essential tool for studies in cell biology and cancer research.KPNA2, also known as Importin alpha-1, plays a crucial role in transporting proteins into the nucleus, allowing for proper cellular function. Dysregulation of KPNA2 has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.
By understanding the function and regulation of KPNA2, researchers can gain insight into disease mechanisms and potentially develop targeted therapies to combat these conditions.Overall, the KPNA2 Polyclonal Antibody (CAB1623) is a valuable resource for researchers interested in studying nucleocytoplasmic transport and its role in disease progression. Its high specificity and reliability make it an essential tool for advancing research in the fields of cell biology and cancer biology.
Product Name:
KPNA2 Rabbit Polyclonal Antibody
SKU:
CAB1623
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2 (NP_002257.1).
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3838
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KPNA2 Rabbit pAb (CAB1623) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
