The KPNA1 Polyclonal Antibody (CAB13623) is a valuable tool for researchers studying importin subunit alpha-1 (KPNA1), a key player in nucleocytoplasmic transport. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in immunofluorescence and immunohistochemistry applications. By targeting KPNA1, this antibody enables the visualization and analysis of nucleocytoplasmic transport processes in various cell types, making it essential for studies in cell biology and gene regulation.
KPNA1 is an essential protein involved in the transport of proteins into the nucleus, playing a crucial role in regulating gene expression and cellular function. Dysregulation of KPNA1 has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in disease progression. Research on KPNA1 is essential for understanding how nucleocytoplasmic transport impacts cellular processes and identifying potential therapeutic targets for treating diseases associated with its dysfunction.
Product Name:
KPNA1 Rabbit Polyclonal Antibody
SKU:
CAB13623
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KPNA1 (NP_002255.3).
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3836
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KPNA1 antibody (CAB13623) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
