[KO Validated] YB-1/YBX1 Rabbit Polyclonal Antibody (CAB7704)
- SKU:
- CAB7704
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | [KO Validated] YB-1/YBX1 Rabbit Polyclonal Antibody |
SKU: | CAB7704 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human YB-1/YB-1/YBX1 (NP_004550.2). |
Sequence: | LRSV GDGE TVEF DVVE GEKG AEAA NVTG PGGV PVQG SKYA ADRN HYRR YPRR RGPP RNYQ QNYQ NSES GEKN EGSE SAPE GQAQ QRRP YRRR RFPP YYMR R |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1; YB-1/YBX1 |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic granule, Nucleus, Secreted. |
Calculated MW: | 36kDa |
Observed MW: | 49kDa |
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes.
Purification Method: | Affinity purification |
Gene ID: | 4904 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |