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[KO Validated] XIAP Rabbit Polyclonal Antibody (CAB6869)

SKU:
CAB6869
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-XIAP Antibody CAB6869KO Validated
  • KO Validated Antibodies 1 Anti-XIAP Antibody CAB6869KO Validated
  • KO Validated Antibodies 1 Anti-XIAP Antibody CAB6869KO Validated
  • KO Validated Antibodies 1 Anti-XIAP Antibody CAB6869KO Validated
  • KO Validated Antibodies 1 Anti-XIAP Antibody CAB6869KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] XIAP Rabbit Polyclonal Antibody
SKU:CAB6869
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 198-497 of human XIAP (NP_001158.2).
Sequence:VQCF CCGG KLKN WEPC DRAW SEHR RHFP NCFF VLGR NLNI RSES DAVS SDRN FPNS TNLP RNPS MADY EARI FTFG TWIY SVNK EQLA RAGF YALG EGDK VKCF HCGG GLTD WKPS EDPW EQHA KWYP GCKY LLEQ KGQE YINN IHLT HSLE ECLV RTTE KTPS LTRR IDDT IFQN PMVQ EAIR MGFS FKDI KKIM EEKI QISG SNYK SLEV LVAD LVNA QKDS MQDE SSQT SLQK EIST EEQL RRLQ EEKL CKIC MDRN IAIV FVPC GHLV TCKQ CAEA VDKC PMCY TVIT FKQK IFMS
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; AP
Positive Sample:MCF-7,HeLa,SW620,HepG2,Jurkat,Mouse liver,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:57kDa
Observed MW:54kDa

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Purification Method:Affinity purification
Gene ID:331
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using XIAP antibody (CAB6869) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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