The XIAP Polyclonal Antibody (CAB6869) is a key tool for researchers studying XIAP, a protein known for its role in regulating cell apoptosis and immune response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the XIAP protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in immunology, cancer research, and beyond.XIAP, also known as X-linked inhibitor of apoptosis protein, is a crucial factor in cell survival and the body's defense mechanisms against cancer and other diseases.
By understanding the functions and mechanisms of XIAP, researchers can gain insights into potential therapeutic strategies for conditions such as cancer, autoimmune disorders, and inflammatory diseases. The XIAP Polyclonal Antibody (CAB6869) provides a reliable tool for investigating these important biological processes and developing new treatments that target XIAP pathways.
Product Name:
[KO Validated] XIAP Rabbit Polyclonal Antibody
SKU:
CAB6869
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 198-497 of human XIAP (NP_001158.2).
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Purification Method:
Affinity purification
Gene ID:
331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using XIAP antibody (CAB6869) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
