[KO Validated] VRK1 Rabbit Polyclonal Antibody (CAB19938)
- SKU:
- CAB19938
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | [KO Validated] VRK1 Rabbit Polyclonal Antibody |
SKU: | CAB19938 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-396 of human VRK1 (NP_003375.1). |
Sequence: | GHLP WEDN LKDP KYVR DSKI RYRE NIAS LMDK CFPE KNKP GEIA KYME TVKL LDYT EKPL YENL RDIL LQGL KAIG SKDD GKLD LSVV ENGG LKAK TITK KRKK EIEE SKEP GVED TEWS NTQT EEAI QTRS RTRK RVQK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PCH1; PCH1A; K1 |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, cytoskeleton, spindle. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Purification Method: | Affinity purification |
Gene ID: | 7443 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |