Anti-TXNDC5 Antibody (CAB19931)[KO Validated]
- SKU:
- CAB19931
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TXNDC5 Antibody (CAB19931)[KO Validated]
The TXNDC5 Polyclonal Antibody (CAB19931) is a valuable tool for researchers studying TXNDC5, a protein involved in redox regulation and cellular stress response. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TXNDC5, this antibody enables the detection and analysis of the protein in various cell types, making it ideal for studies in molecular biology and cell signaling pathways.TXNDC5, also known as thioredoxin domain-containing protein 5, plays a crucial role in maintaining cellular redox balance and protecting cells from oxidative damage.
Its involvement in cellular stress response pathways makes it a promising target for research on diseases related to oxidative stress, such as neurodegenerative disorders and cardiovascular diseases. Understanding the function of TXNDC5 could lead to the development of new therapeutic strategies aimed at modulating redox homeostasis in these conditions.
| Antibody Name: | Anti-TXNDC5 Antibody [KO Validated] |
| Antibody SKU: | CAB19931 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TXNDC5. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human TXNDC5. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 81567 |
| Uniprot: | Q8NBS9 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 36kDa/47kDa |
| Observed MW: | 50KDa |
![Anti-TXNDC5 Antibody [KO Validated] (CAB19931)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/u/221/A19931_1__05695.jpg) | Western blot analysis of extracts from normal (control) and TXNDC5 knockout (KO) 293T cells, using TXNDC5 antibody (CAB19931) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | TXNDC5, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 |
| Background: | This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. |
| UniProt Protein Function: | TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q8NBS9 |
| NCBI GenInfo Identifier: | 29839560 |
| NCBI Gene ID: | 81567 |
| NCBI Accession: | Q8NBS9.2 |
| UniProt Related Accession: | Q8NBS9 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin domain-containing protein 5 |
| NCBI Synonym Full Names: | thioredoxin domain containing 5 |
| NCBI Official Symbol: | TXNDC5Â Â |
| NCBI Official Synonym Symbols: | HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDIÂ Â |
| NCBI Protein Information: | thioredoxin domain-containing protein 5 |
| UniProt Protein Name: | Thioredoxin domain-containing protein 5 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46 |
| UniProt Gene Name: | TXNDC5Â Â |
| UniProt Entry Name: | TXND5_HUMAN |
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