Anti-TXNDC5 Antibody (CAB19930)[KO Validated]
- SKU:
- CAB19930
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TXNDC5 Antibody (CAB19930)[KO Validated]
The TXNDC5 Polyclonal Antibody (CAB19930) is a valuable tool for researchers studying TXNDC5, a protein involved in various cellular processes including redox regulation and protein folding. This rabbit polyclonal antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the TXNDC5 protein, this antibody allows for accurate detection and analysis in a range of cell types, making it ideal for research in fields such as biochemistry, molecular biology, and cell biology.
TXNDC5, also known as thioredoxin domain-containing protein 5, plays a crucial role in maintaining cellular redox balance and protein structure. Its involvement in these essential pathways highlights its importance in various physiological and pathological conditions. Research on TXNDC5 is valuable for understanding diseases related to protein misfolding, oxidative stress, and neurodegeneration, making this antibody a valuable tool for scientists investigating these areas of study.
| Antibody Name: | Anti-TXNDC5 Antibody [KO Validated] |
| Antibody SKU: | CAB19930 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TXNDC5. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human TXNDC5. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 81567 |
| Uniprot: | Q8NBS9 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 36kDa/47kDa |
| Observed MW: | 50KDa |
![Anti-TXNDC5 Antibody [KO Validated] (CAB19930)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/v/322/A19930_1__95904.jpg) | Western blot analysis of extracts from normal (control) and TXNDC5 knockout (KO) 293T cells, using TXNDC5 antibody (CAB19930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | TXNDC5, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 |
| Background: | This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. |
| UniProt Protein Function: | TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q8NBS9 |
| NCBI GenInfo Identifier: | 29839560 |
| NCBI Gene ID: | 81567 |
| NCBI Accession: | Q8NBS9.2 |
| UniProt Related Accession: | Q8NBS9 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin domain-containing protein 5 |
| NCBI Synonym Full Names: | thioredoxin domain containing 5 |
| NCBI Official Symbol: | TXNDC5Â Â |
| NCBI Official Synonym Symbols: | HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDIÂ Â |
| NCBI Protein Information: | thioredoxin domain-containing protein 5 |
| UniProt Protein Name: | Thioredoxin domain-containing protein 5 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46 |
| UniProt Gene Name: | TXNDC5Â Â |
| UniProt Entry Name: | TXND5_HUMAN |
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