Anti-TWF2 Antibody (CAB19898)[KO Validated]
- SKU:
- CAB19898
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TWF2 Antibody (CAB19898)[KO Validated]
The TWF2 Polyclonal Antibody (CAB19898) is a reliable tool for researchers studying the TWF2 protein, a key player in regulating actin dynamics and cell migration. This antibody, derived from rabbit sources, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding specifically to the TWF2 protein, this antibody enables precise detection and analysis in a variety of cell types, offering valuable insights into cellular processes related to cytoskeletal organization and cell motility.
TWF2, also known as Twinfilin-2, is essential for controlling actin filament turnover and promoting efficient cell movement. Dysregulation of TWF2 has been implicated in various diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target. By investigating the role of TWF2 in cellular functions, researchers can deepen their understanding of disease mechanisms and potentially discover new treatment strategies.
| Antibody Name: | Anti-TWF2 Antibody [KO Validated] |
| Antibody SKU: | CAB19898 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TWF2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human TWF2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11344 |
| Uniprot: | Q6IBS0 |
| Cellular Location: | Cell projection, Cytoplasm, cytoskeleton, perinuclear region, stereocilium |
| Calculated MW: | 39kDa |
| Observed MW: | 40KDa |
![Anti-TWF2 Antibody [KO Validated] (CAB19898)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/n/162/A19898_1__84065.jpg) | Western blot analysis of extracts from normal (control) and TWF2 knockout (KO) 293T cells, using TWF2 antibody (CAB19898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
| Synonyms: | TWF2, A6RP, A6r, MSTP011, PTK9L |
| Background: | The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. |
| UniProt Protein Function: | A6r: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: stereocilium; cytoskeleton; growth cone; myofibril; lamellipodium; perinuclear region of cytoplasm; cytoplasm; filopodium Molecular Function:actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; protein kinase C binding; ATP binding Biological Process: cell projection organization and biogenesis; sequestering of actin monomers; negative regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; positive regulation of axon extension; regulation of microvillus length; barbed-end actin filament capping |
| NCBI Summary: | The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6IBS0 |
| NCBI GenInfo Identifier: | 94730596 |
| NCBI Gene ID: | 11344 |
| NCBI Accession: | Q6IBS0.2 |
| UniProt Secondary Accession: | Q6IBS0,Q9Y3F5, |
| UniProt Related Accession: | Q6IBS0 |
| Molecular Weight: | 349 |
| NCBI Full Name: | Twinfilin-2 |
| NCBI Synonym Full Names: | twinfilin actin-binding protein 2 |
| NCBI Official Symbol: | TWF2Â Â |
| NCBI Official Synonym Symbols: | A6r; A6RP; PTK9L; MSTP011Â Â |
| NCBI Protein Information: | twinfilin-2; A6-related protein; twinfilin-1-like protein; twinfilin, actin-binding protein, homolog 2; protein tyrosine kinase 9-like (A6-related protein); PTK9L protein tyrosine kinase 9-like (A6-related protein) |
| UniProt Protein Name: | Twinfilin-2 |
| UniProt Synonym Protein Names: | A6-related protein; hA6RP; Protein tyrosine kinase 9-like; Twinfilin-1-like protein |
| Protein Family: | Twinfilin |
| UniProt Gene Name: | TWF2Â Â |
| UniProt Entry Name: | TWF2_HUMAN |
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