The TSC22D3 Polyclonal Antibody (CAB19911) is a valuable tool for researchers studying TSC22D3, a transcription factor linked to various biological processes, including stress response, cell proliferation, and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards TSC22D3 protein in human samples, making it suitable for Western blot applications.TSC22D3, also known as glucocorticoid-induced leucine zipper protein (GILZ), is involved in mediating anti-inflammatory effects and has been implicated in immune regulation and cancer progression. By targeting TSC22D3 with this antibody, researchers can investigate its role in immune responses, cell signaling pathways, and disease development.
The ability to detect and analyze TSC22D3 in different cell types makes this antibody a valuable asset for investigations in immunology, oncology, and related fields.Understanding the function and regulation of TSC22D3 is essential for elucidating its impact on cellular processes and disease pathogenesis. The TSC22D3 Polyclonal Antibody (CAB19911) provides a reliable tool for researchers to explore the functions of TSC22D3 and its potential as a therapeutic target in various disease conditions.
Product Name:
[KO Validated] TSC22D3 Rabbit Polyclonal Antibody
SKU:
CAB19911
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 58-134 of human TSC22D3 (NP_004080.2).
Sequence:
MDLV KNHL MYAV REEV EILK EQIR ELVE KNSQ LERE NTLL KTLA SPEQ LEKF QSCL SPEE PAPE SPQV PEAP GGSA V
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:
DIP; GILZ; DSIPI; TSC-22R; D3
Positive Sample:
293T
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
15kDa
Observed MW:
16kDa
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1831
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and TSC22D3 knockout (KO) 293T cells, using [KO Validated] TSC22D3 Rabbit pAb (CAB19911) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
