The TRMT2A Polyclonal Antibody (CAB19987) is a valuable tool for researchers studying TRMT2A, a protein involved in RNA modification and cellular metabolism. Raised in rabbits, this antibody is highly specific to human TRMT2A samples and has been validated for use in Western blot applications. By binding to the TRMT2A protein, this antibody enables the detection and analysis of TRMT2A expression in various cell types, making it an essential asset for studies in molecular biology and cancer research.TRMT2A plays a crucial role in maintaining cellular homeostasis by regulating RNA modifications that impact gene expression and protein synthesis.
Its involvement in cellular metabolism and growth processes highlights its significance in understanding diseases such as cancer, metabolic disorders, and neurodegenerative diseases. By studying the function of TRMT2A, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Antibody Name:
Anti-TRMT2A Antibody [KO Validated]
Antibody SKU:
CAB19987
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
A synthetic peptide of human TRMT2A.
Application:
WB IHC
Recommended Dilution:
WB 1:500 - 1:1000 IHC 1:50 - 1:200
Reactivity:
Human, Mouse, Rat
Positive Samples:
HeLa
Immunogen:
A synthetic peptide of human TRMT2A.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
27037
Uniprot:
Q8IZ69
Cellular Location:
Calculated MW:
61kDa/68kDa
Observed MW:
80KDa
Western blot analysis of extracts from normal (control) and TRMT2A knockout (KO) HeLa cells, using TRMT2A antibody (CAB19987) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Synonyms:
TRMT2A, HTF9C
Background:
The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene.
UniProt Protein Function:
HTF9C: May be involved in nucleic acid metabolism and/or modifications. 2 isoforms of the human protein are produced by alternative splicing.
The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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