The TRMT2A Polyclonal Antibody (CAB19929) is a valuable tool for researchers studying TRMT2A, a key player in RNA modification and gene expression regulation. This antibody, produced in rabbits, is highly specific for TRMT2A in human samples and has been validated for use in Western blot applications.TRMT2A is an essential protein involved in tRNA methylation, a process critical for maintaining protein synthesis fidelity and cell viability. Dysregulation of TRMT2A has been linked to various diseases, including cancer and neurodevelopmental disorders.
By targeting TRMT2A, researchers can gain insight into how RNA modification impacts cellular processes and potentially develop targeted therapies for TRMT2A-related conditions.With its high reactivity and specificity, the TRMT2A Polyclonal Antibody enables precise detection and analysis of TRMT2A in a variety of cell types. This makes it an invaluable tool for advancing studies in RNA biology, cancer research, and other fields where TRMT2A's functions are of interest.
Antibody Name:
Anti-TRMT2A Antibody [KO Validated]
Antibody SKU:
CAB19929
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC
Reactivity:
Human
Host Species:
Rabbit
Immunogen:
Recombinant protein of human TRMT2A.
Application:
WB IHC
Recommended Dilution:
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:
Human
Positive Samples:
HeLa
Immunogen:
Recombinant protein of human TRMT2A.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
27037
Uniprot:
Q8IZ69
Cellular Location:
Calculated MW:
61kDa/68kDa
Observed MW:
75KDa
Western blot analysis of extracts from normal (control) and TRMT2A knockout (KO) HeLa cells, using TRMT2A antibody (CAB19929) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:
TRMT2A, HTF9C
Background:
The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene.
UniProt Protein Function:
HTF9C: May be involved in nucleic acid metabolism and/or modifications. 2 isoforms of the human protein are produced by alternative splicing.
The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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