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[KO Validated] TRAF2 Rabbit Polyclonal Antibody (CAB0962)

SKU:
CAB0962
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-TRAF2 Antibody CAB0962KO Validated
  • KO Validated Antibodies 1 Anti-TRAF2 Antibody CAB0962KO Validated
  • KO Validated Antibodies 1 Anti-TRAF2 Antibody CAB0962KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] TRAF2 Rabbit Polyclonal Antibody
SKU:CAB0962
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2).
Sequence:MAAA SVTP PGSL ELLQ PGFS KTLL GTKL EAKY LCSA CRNV LRRP FQAQ CGHR YCSF CLAS ILSS GPQN CAAC VHEG IYEE GISI LESS SAFP DNAA RREV ESLP AVCP SDGC TWKG TLKE YESC HEGR CPLM LTEC PACK GLVR LGEK ERHL EHEC PERS LSCR HCRA PCCG ADVK AHHE VCPK FPLT CDGC GKKK IPRE KFQD HVKT CGKC RVPC RFHA IGCL ETVE GEKQ QEHE VQWL REHL AMLL SSVL EAKP LLGD QSHA GSEL LQRC ESLE KKTA TFEN IVCV LNRE VERV AMTA
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:TRAP; TRAP3; RNF117; MGC:45012; TRAF2
Positive Sample:HeLa,293T,THP-1,PC-12,Ramos,Jurkat,NIH/3T3
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:56kDa
Observed MW:54kDa

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Purification Method:Affinity purification
Gene ID:7186
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using TRAF2 Rabbit pAb (CAB0962) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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