[KO Validated] TRAF2 Rabbit Polyclonal Antibody (CAB0962)
- SKU:
- CAB0962
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | [KO Validated] TRAF2 Rabbit Polyclonal Antibody |
SKU: | CAB0962 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2). |
Sequence: | MAAA SVTP PGSL ELLQ PGFS KTLL GTKL EAKY LCSA CRNV LRRP FQAQ CGHR YCSF CLAS ILSS GPQN CAAC VHEG IYEE GISI LESS SAFP DNAA RREV ESLP AVCP SDGC TWKG TLKE YESC HEGR CPLM LTEC PACK GLVR LGEK ERHL EHEC PERS LSCR HCRA PCCG ADVK AHHE VCPK FPLT CDGC GKKK IPRE KFQD HVKT CGKC RVPC RFHA IGCL ETVE GEKQ QEHE VQWL REHL AMLL SSVL EAKP LLGD QSHA GSEL LQRC ESLE KKTA TFEN IVCV LNRE VERV AMTA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | TRAP; TRAP3; RNF117; MGC:45012; TRAF2 |
Positive Sample: | HeLa,293T,THP-1,PC-12,Ramos,Jurkat,NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 56kDa |
Observed MW: | 54kDa |
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Purification Method: | Affinity purification |
Gene ID: | 7186 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |