The TMPO Polyclonal Antibody (CAB2534) is a vital tool for researchers studying the role of TMPO, a protein involved in nuclear envelope structure and function. This antibody, produced in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.TMPO, also known as lamina-associated polypeptide 2, plays a crucial role in maintaining nuclear architecture and regulating gene expression. Aberrant expression or mutations in TMPO have been linked to diseases such as cancer and muscular dystrophy, making it an important target for further investigation.
With the TMPO Polyclonal Antibody, researchers can accurately detect and analyze TMPO levels in various cell types, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable asset for studies in cell biology, genetics, and disease pathology.
Product Name:
[KO Validated] TMPO Rabbit Polyclonal Antibody
SKU:
CAB2534
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-410 of human TMPO (NP_001027454.1).
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription.
Purification Method:
Affinity purification
Gene ID:
7112
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TMPO Rabbit pAb (CAB2534) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
