Anti-TIMM17A Antibody (CAB19918)[KO Validated]
- SKU:
- CAB19918
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TIMM17A Antibody (CAB19918)[KO Validated]
The TIMM17A Polyclonal Antibody (CAB19918) is a valuable tool for researchers studying TIMM17A, a key protein involved in mitochondrial protein import and assembly. This rabbit polyclonal antibody is highly specific and reacts strongly with human samples, making it ideal for use in Western blot applications. By binding to TIMM17A, this antibody enables precise detection and analysis of the protein in various cell types.TIMM17A is essential for the import of nuclear-encoded mitochondrial proteins into the mitochondria, where they perform crucial functions in energy production and cellular metabolism. Dysregulation of TIMM17A has been linked to various diseases, including neurodegenerative disorders and metabolic diseases.
Research into TIMM17A can provide insights into mitochondrial dysfunction and potential therapeutic targets for these conditions.By utilizing the TIMM17A Polyclonal Antibody in their studies, researchers can gain a deeper understanding of mitochondrial protein import processes and their implications for human health. This antibody is a valuable tool for investigations in mitochondrial biology, bioenergetics, and related fields, offering important insights into the role of TIMM17A in cellular function and disease development.
| Antibody Name: | Anti-TIMM17A Antibody [KO Validated] |
| Antibody SKU: | CAB19918 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TIMM17A. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human TIMM17A. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10440 |
| Uniprot: | Q99595 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 18kDa |
| Observed MW: | 16KDa |
![Anti-TIMM17A Antibody [KO Validated] (CAB19918)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/j/193/A19918_1__95786.jpg) | Western blot analysis of extracts from normal (control) and TIMM17A knockout (KO) 293T cells, using TIMM17A antibody (CAB19918) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | TIMM17A, TIM17, TIM17A |
| Background: |
| UniProt Protein Function: | TIMM17A: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Belongs to the Tim17/Tim22/Tim23 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: mitochondrial inner membrane; integral to mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex Molecular Function:P-P-bond-hydrolysis-driven protein transmembrane transporter activity Biological Process: cellular protein metabolic process; protein targeting to mitochondrion |
| UniProt Code: | Q99595 |
| NCBI GenInfo Identifier: | 3219818 |
| NCBI Gene ID: | 10440 |
| NCBI Accession: | Q99595.1 |
| UniProt Secondary Accession: | Q99595,Q9BWF5, B2RDM5, |
| UniProt Related Accession: | Q99595 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 17 homolog A (yeast) |
| NCBI Official Symbol: | TIMM17AÂ Â |
| NCBI Official Synonym Symbols: | TIM17; TIM17AÂ Â |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit Tim17-A; preprotein translocase; mitochondrial inner membrane translocase; inner membrane preprotein translocase Tim17a |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| UniProt Synonym Protein Names: | Inner membrane preprotein translocase Tim17a |
| Protein Family: | Mitochondrial import inner membrane translocase |
| UniProt Gene Name: | TIMM17AÂ Â |
| UniProt Entry Name: | TI17A_HUMAN |
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