Anti-TIMM17A Antibody (CAB19917)[KO Validated]
- SKU:
- CAB19917
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TIMM17A Antibody (CAB19917)[KO Validated]
The TIMM17A Polyclonal Antibody (CAB19917) is an essential tool for research involving TIMM17A, a key protein involved in the transport of proteins into mitochondria. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it an ideal choice for studying mitochondrial protein import mechanisms.TIMM17A plays a crucial role in maintaining mitochondrial function and is essential for cell survival. Dysfunction of TIMM17A has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. By using this validated antibody in Western blot applications, researchers can investigate the expression levels of TIMM17A in different cell types and gain insights into mitochondrial protein import pathways.
With its high specificity and reliability, the TIMM17A Polyclonal Antibody is a valuable tool for studying mitochondrial biology and exploring potential therapeutic targets for mitochondrial-related diseases. Researchers in the fields of cell biology, biochemistry, and molecular biology will benefit from the use of this antibody in their research endeavors.
| Antibody Name: | Anti-TIMM17A Antibody [KO Validated] |
| Antibody SKU: | CAB19917 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TIMM17A. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human TIMM17A. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10440 |
| Uniprot: | Q99595 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 18kDa |
| Observed MW: | 16KDa |
![Anti-TIMM17A Antibody [KO Validated] (CAB19917)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/g/626/A19917_1__54406.jpg) | Western blot analysis of extracts from normal (control) and TIMM17A knockout (KO) 293T cells, using TIMM17A antibody (CAB19917) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | TIMM17A, TIM17, TIM17A |
| Background: |
| UniProt Protein Function: | TIMM17A: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Belongs to the Tim17/Tim22/Tim23 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: mitochondrial inner membrane; integral to mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex Molecular Function:P-P-bond-hydrolysis-driven protein transmembrane transporter activity Biological Process: cellular protein metabolic process; protein targeting to mitochondrion |
| UniProt Code: | Q99595 |
| NCBI GenInfo Identifier: | 3219818 |
| NCBI Gene ID: | 10440 |
| NCBI Accession: | Q99595.1 |
| UniProt Secondary Accession: | Q99595,Q9BWF5, B2RDM5, |
| UniProt Related Accession: | Q99595 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 17 homolog A (yeast) |
| NCBI Official Symbol: | TIMM17AÂ Â |
| NCBI Official Synonym Symbols: | TIM17; TIM17AÂ Â |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit Tim17-A; preprotein translocase; mitochondrial inner membrane translocase; inner membrane preprotein translocase Tim17a |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit Tim17-A |
| UniProt Synonym Protein Names: | Inner membrane preprotein translocase Tim17a |
| Protein Family: | Mitochondrial import inner membrane translocase |
| UniProt Gene Name: | TIMM17AÂ Â |
| UniProt Entry Name: | TI17A_HUMAN |
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