Anti-TFRC Antibody (CAB18083)[KO Validated]
- SKU:
- CAB18083
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-TFRC Antibody (CAB18083)[KO Validated]
The TFRC Polyclonal Antibody (CAB18083) is a valuable tool for researchers studying Transferrin Receptor (TFRC), a protein involved in iron metabolism and cellular uptake of iron-bound transferrin. The antibody, derived from rabbit hosts, is highly specific to human samples and has been rigorously validated for Western blot applications. By binding to the TFRC protein, this antibody enables precise detection and analysis in a variety of cell types, making it a versatile choice for studies in areas such as cell biology and disease pathology.TFRC plays a crucial role in the regulation of iron homeostasis and is a key player in processes such as cell growth, differentiation, and proliferation.
Dysregulation of TFRC expression has been linked to various diseases, including cancer and iron-related disorders. Investigating the function and regulation of TFRC is essential for gaining insight into the underlying mechanisms of these conditions and developing targeted therapies.Overall, the TFRC Polyclonal Antibody is an indispensable tool for researchers aiming to explore the role of TFRC in health and disease. Its high specificity and reliability make it a valuable asset in the quest for a deeper understanding of iron metabolism and its implications in various pathological conditions.
| Antibody Name: | Anti-TFRC Antibody [KO Validated] |
| Antibody SKU: | CAB18083 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFRC (NP_001121620.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFRC (NP_001121620.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMDQ ARSA FSNL FGGE PLSY TRFS LARQ VDGD NSHV EMKL AVDE EENA DNNT KANV TKPK RCSG SICY GTIA VIVF FLIG FMIG YLGY CKGV EPKT ECER LAGT ESPV REEP GEDF PAAR RLYW DDLK RKLS EKLD STDF |
| Gene ID: | 7037 |
| Uniprot: | P02786 |
| Cellular Location: | Cell membrane, Melanosome, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 84kDa |
| Observed MW: | 105kDa |
![Anti-TFRC Antibody [KO Validated] (CAB18083)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/q/633/A18083_1__35888.jpg) | Western blot analysis of extracts from normal (control) and TFRC knockout (KO) HeLa cells, using TFRC antibody (CAB18083) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | TFRC, CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 |
| Background: | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. |
| UniProt Protein Function: | TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q29 Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome Molecular Function:double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport |
| NCBI Summary: | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P02786 |
| NCBI GenInfo Identifier: | 108935939 |
| NCBI Gene ID: | 7037 |
| NCBI Accession: | P02786.2 |
| UniProt Secondary Accession: | P02786,Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 D3DXB0, |
| UniProt Related Accession: | P02786 |
| Molecular Weight: | 84,871 Da |
| NCBI Full Name: | Transferrin receptor protein 1 |
| NCBI Synonym Full Names: | transferrin receptor |
| NCBI Official Symbol: | TFRCÂ Â |
| NCBI Official Synonym Symbols: | T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46Â Â |
| NCBI Protein Information: | transferrin receptor protein 1 |
| UniProt Protein Name: | Transferrin receptor protein 1 |
| UniProt Synonym Protein Names: | T9; p90; CD_antigen: CD71 |
| Protein Family: | Transferrin receptor protein |
| UniProt Gene Name: | TFRCÂ Â |
| UniProt Entry Name: | TFR1_HUMAN |
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